|
KMID : 1157520100060020055
|
|
International Journal of Clinical Preventive Dentistry
2010 Volume.6 No. 2 p.55 ~ p.61
|
|
|
Clinical Study on Effects of Dentifrice Containing 0.05% Isopropyl Methylphenol (IPMP) and 0.05% Dipotassium Glycyrrhizinate (GK2) on Gingival Conditions
|
|
Park Yong-Duk
Cho Ja-Won
Seo Woo-Seok
Park Hae-Hoon
Shin Seung-Chul
Sano Hiroshi
Kambara Masaki
|
|
|
Abstract
|
|
|
Objective: The purpose of this clinical study is to determine the effect of dentifrice containing 0.05% Isopropyl methylphenol (IPMP) and 0.05% Dipotassium glycyrrhizinate (GK2) on improvement of gingivitis related symptoms.
Materials and Method: Double blind clinical study was carried out in 120 healthy Korean adults to evaluate the improvement effect of test dentifrices for 3 month. All subjects (range of age: 23-35) were randomly assigned into 4 groups, 1) control (without both IPMP and GK2), 2) 0.05% IPMP/ 0.05% GK2 group, 3) 0.05% IPMP group and 4) 0.05% GK2 group. All subjects were provided with their assigned test dentifrice and soft-bristled toothbrush for home use. Subjects were instructed to brush their teeth for 3 minutes three times daily using only the dentifrice and toothbrush provided.
Results: After 3 month test period, IPMP/GK2 group showed statistically significant (p＜0.05) reductions for halitosis (17.5%), Plaque index (36.5%), gingival crevicular fluid (34.7%), periodontal pocket depth (13.1%), and Gingival index (16.0%) compared to control group.
Conclusion: The dentifrice containing of 0.05% IPMP and 0.05% GK2 showed the most efficient in improving the gingivitis related symptoms. These findings might suggest that a combination of IPMP and GK2 showed a synergistic effect or special mode of action.
|
|
|
KEYWORD
|
|
|
isopropyl methylphenol (IPMP), dipotassium glycyrrhizinate (GK2), dentifrice, plaque index, gingival index
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
|